Redwan Moqbel

Dr. Redwan Moqbel, PhD PRCPath

Professor Emeritus (Deceased)

Highlighted Publications

  • Shaw RJ, Walsh GM, Cromwell O, Moqbel R, Spry CJF, Kay AB. 1985. Activated human eosinophils generate SRS-A leukotrienes following physiological (IgG-dependent) stimulation. Nature, (London) 316:150-152.
  • Kay AB, Ying S, Varney V, Gaga M, Durham SR. Moqbel R, Wardlaw AJ, Hamid Q. 1991. Messenger RNA expression of the cytokine gene cluster, IL-3, IL-4, IL-5 and GM-CSF in allergen-induced late-phase cutaneous reactions in atopic subjects. Journal of Experimental Medicine, 173:775-778.
  • Hamid Q, Azzawi M, Ying S, Moqbel R, Wardlaw AJ, Corrigan CJ, Bradley B, Durham SR, Collins JV, Jeffery PK, Quint DJ, Kay AB. 1991. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. Journal of Clinical Investigation, 87:1541-49.
  • Moqbel R, Hamid Q, Ying S, Barkans J, Hartnell A, Tsicopoulos A, Wardlaw AJ, Kay AB. 1991. Expression of mRNA and immunoreactivity for the granulocyte/macrophage colony-stimulating factor (GM-CSF) in activated human eosinophils. Journal of Experimental Medicine, 174:749-752.
  • Hamid Q, Barkans J, Abrams JS, Meng Q, Ying S, Kay AB., Moqbel R. 1992. Human eosinophils synthesize and secrete interleukin-6 in vitro. Blood, 80:1496-1501.
  • Anwar ARE, Moqbel R, Walsh GM, Kay AB, Wardlaw AJ. 1993. Adhesion to fibronectin prolongs eosinophil survival. Journal of Experimental Medicine, 177:839-843.
  • Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R., Totty NF, Truong O, Hsuan JJ, Williams TJ. 1994. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. Journal of Experimental Medicine, 179:881-887.
  • Lacy P, Mahmudi-Azer S, Bablitz B, Hagen SC, Velazquez JR, Man SFP, Moqbel R. 1999. Rapid mobilization and release of intracellularly stored RANTES in response to interferon-g in human eosinophils. Blood, 94: 23-32.
  • Lacy P, Logan MR, Bablitz B, Moqbel R. 2001. The fusion protein, vesicle-associated membrane protein-2 (VAMP-2) is implicated in interferon-g-induced piecemeal degranulation in human eosinophils from atopic individuals. Journal of Allergy and Clinical Immunology 107: 671-678.
  • Logan MR, Lacy P, Bablitz B, Moqbel R. 2002. Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis. Journal of Allergy and Clinical Immunology 109: 299-306.
  • Mahmudi-Azer S, Downey GM, Moqbel R. 2002. Translocation of the tetraspanin CD63 in association with human eosinophil mediator release. Blood 99: 4039-4047.
  • McNaughton L, Puttagunta L, Martinez-Cuesta MA, Kneteman N, Mayers I, Moqbel R, Hamid Q, Radomski MW. 2002. Distribution of nitric oxide synthase in normal and cirrhotic human liver. Proceedings of the National Academy of Science (PNAS), 99: 17161-17166.
  • Lacy P, Abdel Latif D, Steward M, Musat-Marcu S, Man SFP, Moqbel R. 2002. Divergence of mechanisms regulating respiratory burst between human eosinophils and neutrophils from atopic asthma blood and sputum. Journal of Immunology, 170:2670-2679.
  • Lacy P, Abdel-Latif D, Steward M, Musat-Marcu S, Man SF, Moqbel R. 2003. Divergence of mechanisms regulating respiratory burst in blood and sputum eosinophils and neutrophils from atopic subjects. J Immunol;170(5):2670-9.
  • Saude EJ, Lacy P, Musat-Marcu S, Mayes DC, Bagu J, Man SF, Sykes BD, Moqbel R. 2004. NMR analysis of neutrophil activation in sputum samples from patients with cystic fibrosis. Magn Reson Med;52(4):807-14.
  • Odemuyiwa SO, Ghahary A, Li Y, Puttagunta L, Lee JE, Musat-Marcu S, Ghahary A, Moqbel R. 2004. Cutting edge: human eosinophils regulate T cell subset selection through indoleamine 2,3-dioxygenase. J Immunol;173(10):5909-13.
  • Logan MR, Lacy P, Odemuyiwa SO, Steward M, Davoine F, Kita H, Moqbel R. 2006. A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils. Allergy;61(6):777-84.
  • Davoine F, Ferland C, Chakir J, Lee JE, Adamko DJ, Moqbel R, Laviolette M. 2006. Interleukin-12 inhibits eosinophil degranulation and migration but does not promote eosinophil apoptosis. Int Arch Allergy Immunol.;140(4):277-84.

Editorials, Reviews, and Chapters in Books

  • Lacy P, Moqbel R. 2000. Eosinophil Cytokines. In: Human Eosinophils: Biologic and Clinical Aspects, G. M. Marone (Editor). Chemical Immunology Vol. 76. Karger AG (Publishers); 134-155.
  • Hamann KJ, Douglas I, Moqbel R. 2000. Eosinophil Mediators. In: Asthma and Rhinitis, 2nd Edition. Busse W and Holgate ST (Eds). Blackwell Scientific Publications, Oxford. Chapter 29, pp 394-428.
  • Moqbel R, Lacy P. 2000. Molecular mechanisms in eosinophil activation. In: Immunological Mechanisms in Asthma and Allergic Disease, DS Robinson (Editor). Chemical Immunology Series, Karger AG (Publishers) 78: 189-198.
  • Mahmudi-Azer S, Lacy P, Moqbel R. 2001. Tracing intracellular mediator storage and mobilization in eosinophils. In: Human Airway Inflammation: Sampling Techniques and Analytical Protocols. “Methods in Molecular Medicine”, DF Rogers and LE Donnelly (Editors), Humana Press Inc. Totowa, NJ 56: 367-381
  • Lacy P, Moqbel R. 2001. Immune effector functions of eosinophils in allergic airway inflammation. Current Opinion in Allergy and Clinical Immunology 1: 79-84.
  • Lacy P, Weller PF, Moqbel R. 2001. A report from the International Eosinophil Society: Eosinophils in a Tug of War. Special Report. Journal of Allergy and Clinical Immunology 108: 895-900.
  • Adamko D, Lacy P, Moqbel R. 2002. Eosinophil Accumulation and Activation. Current Allergy and Asthma Reports 2: 107-116.
  • Hamid Q, Tulic M, Liu MC, Moqbel R. 2003. Inflammatory cells in asthma: Mechanisms and implications for therapy. J Allergy Clin Immunology, 111: S5-17.
  • Lacy P, Becker AB, Moqbel R. 2003. The human eosinophil. In: Wintrobe's Clinical Haematology, Greer JP, Foerster J, Lukens JN, Rodgers GM, Paraskevas F, Gladder B. (Eds), 11th Edition. Vol 1. Williams and Wilkins, Publishers, Baltimore, USA, PP. 311-334.
  • Adamko D, Odemuyiwa SO, Moqbel R. 2003. The eosinophil as a therapeutic target in asthma: beginning of the end or end of the beginning? Curr Opin Pharmacol.3(3):227-32.
  • Logan MR, Odemuyiwa SO, Moqbel R. 2003. Understanding exocytosis in immune and inflammatory cells: molecular basis of mediator secretion. Journal of Allergy and Clinical Immunology 111: 923-932.
  • Adamko DJ, Lacy P, Moqbel R. 2004. Eosinophil Function in Allergic Inflammation: From Bone Marrow to Tissue Response. Current Allergy and Asthma Reports, 4:149-58.
  • Logan MR, Lacy P, Odemuyiwa SO, Moqbel R. 2004. Membrane fusion events during human eosinophil exocytosis. Allergy and Clinical Immunology International. Allergy Frontiers and Futures, Bienenstock J, Ring J, and Togias AS (Eds); Proceedings of the 24th Symposium of the Collegium Internationale Allergologicum, Bermuda 2002. 157-160.
  • Adamko DJ, Odemuyiwa SO, Vethanayagam D, Moqbel R. 2005. The rise of the Phoenix: The expanding role of the eosinophil in health and disease. Allergy. 60(1):13-22.
  • Moqbel R. Coughlin JJ. 2006. Differential secretion of cytokines. Sci STKE;2006(338):pe26.